Control
Efficacy of FMD vaccines
Key-factors, which determine efficacy of FMD vaccination are:
- Adjuvant:
- Double oil emulsion (DOE) induces a longer duration of immunity than ALSA.
- DOE is suitable for both ruminants as well as for swine, while ALSA is only suitable for ruminants.
- Antigen payload: There is a degree of correlation between the quantity of antigen and the efficacy. There is a ceiling in the quantity for this effect.
- Strain composition: There should be a good correlation between the vaccine strain and the isolated field virus.
- Program: The efficacy of the program depends on a lot of factors. Some of the most important:
- vaccination schedule
- vaccination density,
- vaccine storage and
- administration.
FMD vaccines of sufficient potency start to generate the first degree of protection after 2-3 days
More Information
P. Hunter
The performance of Southern African territories serotypes of foot and mouth disease antigen in oil adjuvanted vaccines
Rev. sci. tech. Off. int. Epiz, 1996, 15(3)
Abstract
